For example, if clonidine is being consumed with opiates to amplify their effect, withdrawal symptoms may be compounded with those of opiate withdrawal.
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chronic dietary administration of clonidine was not carcinogenic to rats 132 weeks or mice 78 weeks dosed, respectively, at up to 46 or 70 times the maximum recommended daily human dose as mg kg 9 or 6 times the mrdhd on a mg m 2 basis .
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