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a small number of people who have taken metformin have developed a serious condition called lactic acidosis that has been fatal in up to 50 of cases.

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the single-dose nature of this study and the lack of correlation between glyburide blood levels and pharmacodynamic effects, makes the clinical significance of this interaction uncertain see dosage and administration concomitant metformin hydrochloride tablets, usp and oral sulfonylurea therapy in adult patients .

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at usual clinical doses and dosing schedules of metformin hydrochloride tablets, steady state plasma concentrations of metformin are reached within 24 to 48 hours and are generally 1 mcg ml.


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