The difference in bioavailability between digoxin-zori injection or digoxin tablets must be considered when changing patients from one dosage form to another.

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quinidine, verapamil, amiodarone, propafenone, indomethacin , itraconazole , alprazolam, and spironolactone raise the serum digoxin concentration due to a reduction in clearance and or in volume of distribution of the drug, with the implication that digitalis intoxication may result.

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nevertheless, caution should be exercised when digoxin-zori is administered to a nursing woman.

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digoxin concentrations are increased by about 15 when digoxin and carvedilol are administered concomitantly.

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flurbiprofen moderate concomitant use of nonsteroidal antiinflammatory drugs nsaids with digoxin may result in increased serum concentrations of digoxin.

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digoxin blood levels are used for adjusting doses in order to avoid toxicity.


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